Table 4.
Comparison of FLC Immunoquantitative Data
| Patient/Diagnosis* | Monoclonal Ig † | anti-FLC polyclonal antibodies‡ | anti-FLC monoclonal antibodies§ | ||||
|---|---|---|---|---|---|---|---|
| κ FLC∥¶ | λ FLC∥¶ | κ:λ FLC¶ | κ FLC∥# | λ FLC∥# | κ:λ # | ||
| FLC¶ | |||||||
| 1/AL | IgGλ | 1.1 | 10.9 | 0.10 | 0.6 | 27.7 | 0.02 |
| 2/MM | IgGκ | 4.1 | 0.6 | 6.83 | 6.6 | 6.2 | 1.06 |
| 3/AL | IgGλ | 1.2 | 1.9 | 0.63 | 1.3 | 50.5 | 0.03 |
| 4/AL | IgGκ | 12.1 | 1.6 | 7.56 | 18.1 | 19.9 | 0.91 |
| 5/AL | BJPκ | 101.0 | 0.2 | 505.0 | 141.5 | 4.1 | 34.51 |
| 6/AL | IgGλ/BJPλ | 0.8 | 40.0 | 0.02 | 1.3 | 43.3 | 0.03 |
| 7/MM | IgGκ | 68.1 | 0.26 | 261.9 | 27.2 | 2.8 | 9.71 |
| 8/MM/AL | BJPκ | 39.1 | 4.20 | 9.31 | 282.1 | 25.6 | 11.02 |
| 9/MM | BJPλ | 0.15 | 74.7 | 0.002 | 0.7 | 71.4 | 0.01 |
| 10/AL | IgAλ | 0.62 | 8.1 | 0.08 | 0.7 | 217.3 | 0.003 |
| 11/AL | BJPλ | 0.96 | 48.7 | 0.02 | 1.2 | 27.8 | 0.04 |
| 12/MM | BJPκ | 35.8 | 1.1 | 32.5 | 35.5 | 6.0 | 5.92 |
AL, AL amyloidosis; MM, multiple myeloma.
Based on immunofixation electrophoresis.
FREELITE™ anti-κ FLC and anti-λ FLC reagents.
anti-κ FLC (Fκ–C8) and anti-λ FLC (Fλ–G9) mAbs.
mg/L.
Normal values: κ, 3.3–19.4; λ, 5.71–26.3; κ:λ, 0.26–1.65.
Normal values: κ, 4.2–13.0; λ, 16.4–127.3; κ:λ, 0.07–0.28.