TABLE 1.
Results of serum galactomannan testing from patients infected with Paracoccidioides brasiliensis, Histoplasma capsulatum, Cryptococcus neoformans, and Cryptococcus gattii
| Agentb | Serum galactomannan optical density indexa
|
No. (%) of samples with optical density index of:
|
|||||
|---|---|---|---|---|---|---|---|
| Range | Mean value | 95% Confidence interval | >2.0 | >1.0 to 2.0 | ≥0.5 to 1.0 | <0.5 | |
| Paracoccidioides brasiliensis | 0.23-5.47 | 0.99 | 0.53-1.44 | 3 (10.0) | 5 (16.6) | 7 (23.3) | 15 (50.0) |
| Histoplasma capsulatum | 0.24-5.38 | 1.43 | 0.88-1.98 | 7 (23.3) | 7 (23.3) | 6 (20.0) | 10 (33.3) |
| Cryptococcus neoformans | 0.18->10 | 1.95 | 0.95-2.94 | 9 (30.0) | 5 (16.6) | 5 (16.6) | 11 (36.6) |
| Cryptococcus gattii | 0.18->9 | 1.03 | 0.38-1.68 | 4 (13.3) | 3 (10.0) | 4 (13.3) | 19 (63.3) |
a
Optical density indexes higher than or equal to 0.5 are considered positive. High indexes (i.e., >1.0) increase the test specificity in the diagnosis of invasive aspergillosis (1).
b
n = 30 (samples) for each group.