TABLE 1.

Bacterial burden in BALB/c mice challenged with Y. pestis^a

Groupb	Y. pestis count (CFU/ml) at 3 days
	Blood	Liver	Lungs	Spleen
Control		3.4 × 105
Control	7 × 106	3.2 × 107	1.3 × 106	8.2 × 107
Control	2.2 × 103	2.1 × 104	1.1 × 106	2.1 × 104
Control	6 × 102	6 × 105	2.8 × 105	8.4 × 105
Control	9.6 × 107	2.1 × 107	9.8 × 108	2.1 × 109
Flagellin-F1-V	0	0	0	0
Flagellin-F1-V	0	0	0	0
Flagellin-F1-V	0	0	0	0
Flagellin-F1-V	0	0	0	0
Flagellin-F1-V	0	0	0	0
Flagellin-F1-V	0	0	0	0

^aGroups of five mice each were given PBS or 10 μg flagellin-F1-V on two occasions and were then challenged with approximately 150 MTD₅₀s of Y. pestis i.n. After 3 days, the mice were killed and the numbers of CFU in the blood, liver, lungs, and spleen were determined.

^bEach line represents the results from a single mouse (PBS or flagellin-F1-V treated).