TABLE 1.
Overview of inhibitory effects of compounds in studied T3SS-carrying pathogens
| Compound | Alternative name(s) (reference) | Effect on (reference)a:
|
Other effects (reference) | |
|---|---|---|---|---|
| T3SS protein secretion/expression | In vitro virulence | |||
| INP0007 | Compound 2 (18), compound 1 (30) | Yersinia, yes (18, 30); Salmonella, yes (15, 29) | Yersinia, yes (30); Salmonella, yes (15, 29) | Yersinia motility (18) |
| INP0010 | Compound 8 (30) | Yersinia, yes (30); Salmonella, yes (29); Chlamydia, yes (3) | Yersinia, yes (3); Salmonella, yes (29); Chlamydia, yes (3) | |
| INP0400 | Salmonella, yes (29); Shigella, yes (this study) | Yersinia, yes (3); Salmonella, yes (29); Chlamydia, yes (28); Shigella, yes (this study) | Shigella T3SS needle assembly (this study) | |
| INP0401 | Compound 10 (30) | Yersinia, yes (30); Salmonella, yes (29); Shigella, yes (this study) | Salmonella, yes (29); Shigella, no (this study) | Shigella T3SS needle assembly (this study) |
| INP0402 | Compound 15 (30) | Yersinia, yes (30); Salmonella, yes (29); Shigella, yes (this study) | Salmonella, yes (29); Shigella, yes (this study) | Shigella T3SS needle assembly (this study) |
| INP0403 | Compound 11 (30) | Yersinia, yes (30); Salmonella, yes (15, 29) | Salmonella, yes (15, 29) | Salmonella induced in vivo inflammatory response (15) |
| INP0404 | Compound 20 (30) | Yersinia, yes (30); Salmonella, yes (29); Shigella, yes (this study) | Salmonella, yes (29); Shigella, yes (this study) | Salmonella motility and flagellin expression (29), Shigella T3SS needle assembly (this study) |
| INP0405 | Compound 9 (30) | Yersinia, yes (30); Salmonella, yes (29); Shigella, yes (this study) | Salmonella, yes (29); Shigella, yes (this study) | Salmonella motility and flagellin expression (29) |
| INP0406 | Yersinia, no (C. Sundin, unpublished data); Salmonella, yes (29); Shigella, no (this study) | Yersinia, no (3); Salmonella, yes (29); Chlamydia, no (3); Shigella, no (this study) | ||
a
T3SS-mediated protein secretion or expression (the latter only for reference 31) and in vitro virulence represent key assays for studying T3SS activity.