TABLE 3.
Effects of inhibitors on secreton needle length
| Needle length (nm) | % of needles (mean ± SD)a after the following addition:
|
||||
|---|---|---|---|---|---|
| INP0400 | INP0400Cb | INP0406 | DMSO | None | |
| <35 | 18 ± 4 | 11 ± 7 | 9 ± 4 | 11 ± 1 | 13 ± 1 |
| 35-63 | 66 ± 10 | 73 ± 4 | 79 ± 5 | 81 ± 9 | 81 ± 6 |
| 63-91 | 15 ± 13 | 15 ± 8 | 10 ± 8 | 8 ± 10 | 5 ± 4 |
| 91-112 | 1 ± 1 | 1 ± 1 | 1 ± 0 | 0 ± 0 | 1 ± 1 |
a
Data derived are from either two or three independent experiments.
b
Control in which Shigella cultures were grown in the absence of compounds and INP0400 was added just prior to the cell lysis step.