TABLE 3.
Trends in in vitro resistance to fluconazole and voriconazole among selected non-Candida yeast species as determined by CLSI disk diffusion testing over a 10.5-year perioda
| Species | Antifungal agent | 1997-2000
|
2001-2004
|
2005-2007
|
|||
|---|---|---|---|---|---|---|---|
| No. of isolates tested | % R | No. of isolates tested | % R | No. of isolates tested | % R | ||
| C. neoformans | Fluconazole | 688 | 7.3 | 1,812 | 10.9 | 1,012 | 11.7 |
| Voriconazole | 1,795 | 1.7 | 1,009 | 1.8 | |||
| S. cerevisiae | Fluconazole | 58 | 5.2 | 552 | 6.3 | 470 | 5.5 |
| Voriconazole | 540 | 2.8 | 470 | 2.6 | |||
| Trichosporon spp. | Fluconazole | 211 | 5.2 | 375 | 9.9 | 169 | 5.9 |
| Voriconazole | 354 | 2.3 | 169 | 2.4 | |||
| T. asahii | Fluconazole | 13 | 0.0 | 15 | 13.3 | 149 | 14.1 |
| Voriconazole | 15 | 13.3 | 92 | 7.6 | |||
| T. beigelii/T. cutaneum | Fluconazole | 25 | 40.0 | 101 | 13.9 | 45 | 6.6 |
| Voriconazole | 99 | 14.1 | 45 | 4.4 | |||
| Rhodotorula spp. | Fluconazole | 78 | 92.3 | 166 | 52.4 | 116 | 47.4 |
| Voriconazole | 164 | 42.1 | 117 | 35.9 | |||
| Blastoschizomyces capitatus | Fluconazole | 1 | 0.0 | 70 | 14.3 | 38 | 7.9 |
| Voriconazole | 70 | 4.3 | 38 | 0.0 | |||
| Pichia spp. | Fluconazole | 7 | 14.3 | 81 | 7.4 | 46 | 26.1 |
| Voriconazole | 79 | 0.0 | 46 | 0.0 | |||
| Total (all non-Candida yeasts) | Fluconazole | 2,446 | 14.2 | 5,158 | 12.2 | 3,636 | 11.9 |
| Voriconazole | 5,084 | 5.3 | 3,576 | 4.5 | |||
a
Includes all specimen types and all hospital locations in 134 institutions. Zone diameters: R, <14 mm for fluconazole, <13 mm for voriconazole. Data for voriconazole are available for 2001 to 2007 only.