TABLE 4.
Geographic variation in azole resistance among selected non-Candida yeastsa
| Region | Antifungal agent |
C. neoformans
|
S. cerevisiae
|
Trichosporon spp.
|
Rhodotorula spp.
|
||||
|---|---|---|---|---|---|---|---|---|---|
| n | % R | n | % R | n | % R | n | % R | ||
| Asia-Pacific | Fluconazole | 530 | 10.8 | 25 | 24.0 | 175 | 8.6 | 149 | 21.5 |
| Voriconazole | 502 | 3.0 | 24 | 12.5 | 175 | 4.0 | 147 | 15.0 | |
| Europe | Fluconazole | 470 | 6.6 | 902 | 5.1 | 415 | 12.3 | 103 | 71.8 |
| Voriconazole | 456 | 1.5 | 893 | 2.4 | 401 | 3.5 | 103 | 62.1 | |
| Africa/Middle East | Fluconazole | 869 | 12.4 | 16 | 0.0 | 37 | 0.0 | 16 | 87.5 |
| Voriconazole | 868 | 1.8 | 16 | 0.0 | 37 | 0.0 | 16 | 75.0 | |
| Latin America | Fluconazole | 595 | 13.6 | 29 | 24.1 | 254 | 7.1 | 55 | 81.2 |
| Voriconazole | 580 | 2.4 | 28 | 10.7 | 245 | 5.3 | 56 | 62.5 | |
| North America | Fluconazole | 255 | 8.1 | 49 | 2.0 | 63 | 6.3 | 58 | 87.9 |
| Voriconazole | 255 | 1.2 | 49 | 0.0 | 63 | 4.8 | 58 | 63.8 | |
a
Isolates were obtained from 133 institutions. The interpretive breakpoints (zone diameters) for resistance (R) were as follows: fluconazole, <14 mm; voriconazole, <13 mm.