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Diameter of long vessels (>200 μm) decreased significantly in the antibody-treated (solid symbols) LS174T tumors transplanted in dorsal skinfold chambers in SCID mice, compared with the controls (open symbols) (P < 0.0001). Vessel diameter and length were measured at various time points postbolus i.v. injection of the anti-VEGF antibody (N = 3) or PBS (N = 3).
