Figure 3.

Photographs showing the reduction of vessel volume in LS174T tumors transplanted in dorsal skinfold chambers after the anti-VEGF/VPF treatment. The photos were taken at various time points both before (day 0; A and D) and after bolus i.p. injections of PBS (B and C) or the anti-VEGF/VPF antibody (E and F) on day 3 (B and E) or 7 (C and F). The injections were given at days 0 and 4, respectively. The size of tumors before treatments was ≈4 mm in diameter. There was a significant decrease in vessel volume of the antibody-treated tumor. Small vessels in this tumor were not visible on days 3 (E) or 7 (F) because of the lower magnification of these images.