Table 4.

Time-dependent changes in vascular volume in LS174T tumors in dorsal skinfold chambers: Total vascular volume/tumor surface area (10⁻⁴ cm³/cm²)^*

Control	Antibody-treated	Time, day
6.87 (6.45–6.89)	1.43  (1.00–2.37)†	1
2.82 (2.57–11.23)	1.82  (1.61–2.01)†	3
3.72 (2.24–10.14)	1.09  (0.70–2.85)	5

The data are shown as median (range). The anti-VEGF antibody (492 μg/ml) (N = 3) or PBS (N = 3) was administered as a bolus i.v. approximately 3 weeks after tumor transplantation, depending on growth rate and vascularization of tumors; and the measurement was performed at various time points postinjections. The dose of each injection was 0.2 ml. 

^*The volume per tumor surface area was calculated using the data of vessel diameter and length. 

^†P < 0.05 vs the matched control.