Table 2.

Effects of the conantokins on formalin-induced edema^a

Peptides b	Injected paw width a (mm)
	Before formalin injection	After formalin injectionc	Increase in paw width
con-G*	1.55 ± 0.02	2.38 ± 0.03	0.83 ± 0.03
con-G[S16Y]*	1.57 ± 0.03	2.33 ± 0.05	0.76 ± 0.05
Ala-con-G	1.60 ± 0.02	2.56 ± 0.05	0.97 ± 0.05
con-R[1-17]	1.60 ± 0.04	2.60 ± 0.05	1.00 ± 0.08
ifenprodil	1.59 ± 0.04	2.70 ± 0.04	1.10 ± 0.05
saline	1.57 ± 0.03	2.53 ± 0.03	0.97 ± 0.05

^aEdema was elicited through injection of 20 μl of 5% formalin in saline into the subplantar region of the right hind paw. Data are presented as mean ± S.D. (n = 8).

^bPeptides (100 pmol) or ifenprodil (25 nmol) were injected intracerebrally (i.c.v.) in a volume of 20 μl.

^cMeasurements were taken 60 min after formalin injection.

^*Significantly diminished paw swelling compared to the saline control group (p < 0.05, unpaired t test).