Table 1. Healthy participants from Jamaica: Test for association of F cell levels with HMIP-2 markers.

HMIP-2 marker	European			Afro-Caribbean			Afro-German			Combined Jamaican Group			Combined Jamaican Group, exclusion of non-African haplotypes
	(n = 76)			(n = 178)			(n = 633)			(n = 811)			(n = 693)
	MAF	β	P =	MAF	β	P =	MAF	β	P =	MAF	β	P =	MAF	β	P =
I-01 (rs9376090)	0.3	0.497	2.6×10−7	0.03	0.528	0.045	0.08	0.161	0.016	0.07	0.141	0.036	0	n a	n a
I-02 (rs9399137)	0.29	0.511	1.5×10−7	0.04	0.559	0.005	0.09	0.196	0.002	0.08	0.206	9.2×10−4	0.02	0.412	0.005
I-03 (rs9402685)	0.29	0.512	1.3×10−7	0.30	0.051	0.579	0.27	0.039	0.341	0.28	0.051	0.183	0.23	0.005	0.908
I-04 (rs11759553)	0.31	0.559	2.7×10−9	0.38	0.135	0.122	0.37	0.123	0.001	0.37	0.127	3.5×10−4	0.33	0.100	0.012
I-05 (rs35959442‡)	0.31	0.524	1.9×10−8	0.36	0.036	0.681	0.36	0.105	0.007	0.36	0.089	0.014	0.32	0.071	0.079
I-06 (rs4895440)	0.3	0.549	2.4×10−9	0.36	0.040	0.650	0.36	0.107	0.005	0.36	0.091	0.012	0.32	0.067	0.093
I-07 (rs4895441)	0.3	0.516	3.7×10−8	0.05	0.428	0.022	0.12	0.181	0.001	0.11	0.168	0.002	0.05	0.144	0.099
I-08 (rs9376092)	0.3	0.516	3.7×10−8	0.18	0.169	0.161	0.21	0.102	0.024	0.2	0.101	0.020	0.15	0.056	0.292
I-09 (rs9389269)	0.3	0.549	2.4×10−9	0.04	0.540	0.010	0.11	0.250	1.3×10−5	0.1	0.237	3.9×10−5	0.03	0.380	6.5×10−4
I-10 (rs9402686)	0.3	0.560	5.6×10−9	0.04	0.550	0.008	0.1	0.242	5.9×10−5	0.09	0.234	1.1×10−4	0.03	0.403	4.4×10−4
I-11 (rs11154792)	0.3	0.484	7.4×10−7	0.13	0.097	0.440	0.15	0.225	1.1×10−5 *	0.15	0.195	6.4×10−5	0.08	0.205	0.003

The multiple-regression model included covariates age, sex, and an additive genetic effect of the XmnI ^Gγ site. The minor-allele frequency (MAF) refers to the same allele in all populations.

Genetic association was also tested in the combined Jamaican group (Afro-Caribbean and Afro-German groups combined). The last column is a repeat of this analysis, after exclusion of individuals who carry the C allele of rs9376090 (I-01, 7 homozygotes and 95 heterozygotes), which tags non-African haplotypes at the HMIP-2 locus. Also excluded were 16 individuals with an unknown genotype at this SNP. Hence, a total of 693 individuals were analysed in the combined Jamaican group.

^*A nominally significant (P = 0.04) dominance effect was detected only for I-11 in the AG group and was included in the regression model for this data point.

^‡ rs35959442 was previously named rs52090909.