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. 2009 Jan 16;4(1):e4212. doi: 10.1371/journal.pone.0004212

Figure 6. Histological and immunohistochemical analysis of the pancreas at E15.5 (A) and P1 (B) of wild-type and Dicer1-hypomorphic mice.

Figure 6

Dicer1-hypomorphic mice show normal insulin (brown) and glucagon (blue) staining at E15.5 and P1. C: Histological abnormalities found in the pancreas of 4-week-old Dicer1-hypomorphic mice. (I) The endocrinal distribution was slightly irregular. The dotted line indicates the abnormal region of the islet. (II) Multi-nucleated cells were observed. The dotted line indicates multi-nucleated cells, which were also found in the pancreas of adult Dicer1-hypomorphic mice.