Figure 2.

Two-dimensional structural representations of the mediator and SAGA complexes, overlaid with filtered yeast interactome (FYI) and predicted domain-domain interaction (DDI) data. (A) and (B) The 2-D representations of the mediator and SAGA complexes are built from structural and interaction data, but note that 3-D structures of these complexes are not known. (C) Pairwise protein interaction data from FYI clearly defined the mediator and SAGA complexes. Interactions between many structurally non-adjacent proteins, however, are seen. (D) Very few domain-domain interactions could be predicted for the mediator or SAGA complexes.