TABLE 7.
Estimating θ in the presence of biased amplification
| X | pe = 0.0 | pe = 0.01 | pe = 0.05 | pe = 0.1 | pe = 0.15 |
|---|---|---|---|---|---|
| 16× | 100.1 (14.4) | 100.0 (14.7) | 101.8 (15.2) | 102.4 (15.1) | 102.6 (15.6) |
| 8× | 100.1 (14.4) | 100.1 (15.4) | 101.9 (15.5) | 102.3 (15.4) | 103.0 (15.9) |
| 4× | 100.2 (14.9) | 101.5 (15.6) | 102.8 (16.5) | 100.6 (15.8) | 103.7 (15.9) |
| 2× | 99.6 (15.7) | 103.7 (16.3) | 105.1 (16.7) | 105.6 (16.5) | 107.3 (18.7) |
Here we set θ0 (the generating value of θ) = 100 and use ρ0 = 20. pe is the probability that a minor allele is not sequenced. We report the mean (and RMSE) of the estimates over 1000 simulations.