Figure 1.—

Reporters to measure the stability of repetitive sequences in mtDNA. (A) The microsatellite reporter. The open arrows indicate the ARG8^m and COX2 coding sequences. The location of the site used for insertion of the microsatellite sequence in the ARG8^m coding sequence is indicated. (B) The mitochondrial direct repeat-mediated deletion reporter. The striped boxes represent the 96 bases of COX2 sequence 3′ of the ATG start. The open arrows indicate the ARG8^m coding sequence, including the ATG start fused in-frame with the COX2 sequences, and the remainder of the COX2 sequence, respectively. Recombination between the repeated sequences restores the functional COX2 gene.