Table 1.
Effect of bupropion HCl 120 mg/kg intraperitoneal infusion times on bupropion HCl-induced percentage of convulsing mice and on odds of convulsing vs not convulsing
| Group* | Intraperitoneal (IP) infusion time (min) | No. of mice convulsing | Convulsing mice | Reduction in odds of convulsing† |
| 1 | 0 (bolus) | 6 | 60% | - |
| 2 | 15 | 9 | 90% | 32.6% |
| 3 | 30 | 5 | 50% | 54.6% |
| 4 | 60 | 5 | 50% | 79.4% |
| 5 | 90 | 0 | 0% | 90.6% |
| 6 | 120 | 2 | 20% | 95.8% |
| 7 | 240 | 0 | 0% | 99.8% |
*Number of mice was 10 for each group, except group 5 that had 9 mice.
†Reduced odds of convulsing vs not convulsing for any infusion time, x min, were calculated using the formula: 1 - (0.974x) × 100%; where 0.974 was the odds ratio estimate obtained from logistic regression analysis, and x = infusion time (min).