Table 2.
Effect of bupropion HCl 120 mg/kg intraperitoneal infusion times on time to onset of bupropion HCl-induced convulsions and on odds of convulsing vs not convulsing in mice
| Group* | Intraperitoneal (IP) infusion time (min) | Time to Onset of Convulsions for Individual Mice (min)† | Reduction in hazard (probability) of convulsing |
| 1 | 0 (bolus) | 7; 30; 6; 120; 5; 11; 120; 120; 23; 120 | - |
| 2 | 15 | 15; 120; 5; 18; 19; 23; 14; 20; 16; 13 | 28.4% |
| 3 | 30 | 20; 120; 17; 120; 120; 120; 120; 39; 42; 31 | 48.7% |
| 4 | 60 | 32; 120; 42; 120; 120; 60; 120; 70; 120; 69 | 73.7% |
| 5 | 90 | 120; 120; 120; 120; 120; 120; 120; 120; 120 | 86.5% |
| 6 | 120 | 120; 9; 41; 120; 120; 120; 120; 120; 120; 120 | 93.1% |
| 7 | 240 | 120; 120; 120; 120; 120; 120; 120; 120; 120; 120 | 99.5% |
*Number of mice was 10 for each group, except group 5 that had 9 mice.
†Mice that did not have convulsions during treatment infusion and by the end of the 2-h post-treatment period were considered to be censored at 120 min.
‡Reduced hazard of convulsing vs not convulsing for any infusion time, x min, was calculated using the formula: 1 - (0.978x) × 100%; where 0.978 was the hazard ratio estimate obtained from Cox proportional hazards model, and x = infusion time (min).