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. 2009 Jan 13;6(1):e1000010. doi: 10.1371/journal.pmed.1000010

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: © 2009 Curtin et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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(A) GL261 cells were implanted into the striatum of C57/Bl6 mice. 17 d later animals were treated with Ad-Flt3L (n = 5), Ad-TK (+GCV) (n = 6), Ad-Flt3L plus Ad-TK (+GCV) (n = 5), or saline (n = 5). Treatment with Ad-Flt3L and Ad-TK significantly improved survival when compared to saline (*, p < 0.05; Mantel log-rank test), Ad-Flt3L, or Ad-TK alone treatment groups (^, p < 0.05; Mantel log-rank test). Treatment with Ad-Flt3L, or Ad-TK alone significantly improved survival when compared to saline (*, p < 0.05; Mantel log-rank test).

(B) 7 d after treatment, tumor-bearing animals were humanely killed and HMGB1 release was assessed in the serum. Treatment of GL261 tumor-bearing animals with Ad-Flt3L and Ad-TK (+GCV) significantly increased the levels of HMGB1 in the serum when compared to tumor-bearing animals treated with saline. *, p < 0.05 versus saline (Mann-Whitney U-test).

(C) B16-F10 cells were implanted into the striatum of C57/Bl6 mice. 17 d later animals were treated with Ad-Flt3L, Ad-TK (+GCV), Ad-Flt3L plus Ad-TK (+GCV), or saline. Treatment with Ad-Flt3L and Ad-TK significantly improved survival when compared to saline (*, p < 0.05; Mantel log-rank test), Ad-Flt3L, or Ad-TK alone treatment groups (^, p < 0.05; Mantel log-rank test). Treatment with Ad-Flt3L, or Ad-TK alone, significantly improved survival when compared to saline (*, p < 0.05; Mantel log-rank test).

(D) 7 d after treatment, tumor-bearing animals were humanely killed and HMGB1 release was assessed in the serum. Treatment of B16-F10 tumor-bearing animals with Ad-Flt3L and Ad-TK (+GCV) significantly increased the levels of HMGB1 in the serum when compared to tumor-bearing animals treated with saline. *, p < 0.05 versus saline (Mann-Whitney U-test).