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. Author manuscript; available in PMC: 2009 Jan 12.
Published in final edited form as: Neurosci Lett. 2008 Apr 20;438(2):210–215. doi: 10.1016/j.neulet.2008.04.054

Fig. 4.

Fig. 4

The EP3 receptor does not transduce the protective effect of misoprostol in MCAO-RP. (A) EP3−/− and +/+ mice do not show differences in infarct volumes at 24 h (n = 10 per genotype). (B) CBF as measured by Laser Doppler flowmetry during ischemia and reperfusion did not show differences between EP3+/+ and −/− mice (n = 4 per condition). (C) Administration of misoprostol to EP3−/− mice results in similar in infarct volume in EP3−/− and +/+ mice (n = 10–11 per group; *p < 0.05). Physiological measurements did not differ between genotypes (see Supplementary Table 2).

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