Skip to main content
. 1996 Dec 10;93(25):14788–14794. doi: 10.1073/pnas.93.25.14788

Figure 1.

Figure 1

Targeted disruption of the mouse apolipoprotein A-II gene. (A) The mouse apo A-II gene locus. Exons 1–4 are represented by black boxes. (B) The gene targeting construction. The neomycin resistant gene (neo) cassette replaced the entire mouse apo A-II gene, including the promoter region. (C) The gene locus after DNA homologous recombination. The 12-kb EcoRI fragment of the endogenous locus was modified to 3.8 kb in the targeted locus. RI, EcoRI; B, BamHI; Sp, SpeI; Sph, SphI; K, KpnI; Xb, XbaI; S, SalI, Bg, BglII.