Table 1.

The plasma cholesterol and triglyceride levels in apo A-II-deficient mice in fed and fasting conditions on chow diet

Mouse	n	TC, mg/dl	TG, mg/dl	Non- HDL-C, mg/dl	HDL, mg/dl
Fasted
+/+	9	85 ± 12	56 ± 13	19 ±  6	66 ± 7
+/−	9	67 ±  8**	44 ± 13	12 ±  5*	55 ± 5**
−/−	9	28 ±  7**	46 ± 13	10 ±  4**	18 ± 4**
Fed
+/+	9	80 ± 10	ND	24 ±  7	56 ± 9
+/−	10	69 ±  8*	ND	22 ±  9	47 ± 6*
−/−	9	38 ±  8**	ND	17 ± 10	20 ± 8**

Plasma cholesterol and triglyceride analyses were performed on littermates. For the fed condition blood was drawn from the retroorbital venous plexus at 9 a.m. For the fasting condition, food was removed at 9 a.m. with the animal having ad lib access to water and blood drawn from the retroorbital venous plexus at 5 p.m. The values of VLDL–LDL were obtained by subtracting total cholesterol with HDL cholesterol. TC, total cholesterol; TG, triglyceride; C, cholesterol. Lipid values are shown as mean ± SD. +/+, +/−, and −/− represent control littermates, heterozygous-deficient mice, and apo A-II-deficient mice, respectively. ND, not determined. 

^*P < 0.05 as compared with control mice. 

^**P < 0.01 as compared with control mice. 

^**P < 0.001 as compared with control mice.