Figure 4.

Glucose tolerance test in ob/ob mice after leptin gene treatment. The ob/ob mice were injected with Ad.RSV-mLeptin (•) or Ad.RSV-hAAT (▵) at 3 × 10⁹ pfu/mouse or PBS only (○). Five weeks (A) and 17 weeks (B) after injection, glucose tolerance test were performed on treated mice. Blood glucose were measured prior to and at indicated times after intraperitoneal glucose injection. Glucose tolerance test was also performed with age-matched C57BL/6J mice (▪) for comparison. Each value represents mean ± SEM of six to eight mice.