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Cytotoxicity of immunotoxins on different cell lines
| Immunotoxin | Cell lines
|
||
|---|---|---|---|
| NR6M | U87MG.ΔEGFR | U87MG | |
| MR1scFvPE38KDEL | 1(16) | 7–10 (110-160) | >1000 |
| 2 h | 30(480) | ||
| 48 h | 0.5–0.6 (8-10) | ||
| MR1scFvPE38REDLK | 3–4 (48-64) | 40(640) | >1000 |
The concentration of immunotoxin at which 50% inhibition of protein synthesis occurs (IC50) is given in ng/ml with the value in pM in parentheses. All values are for 24-h exposure to immunotoxin unless stated otherwise.
