Figure 1.

Acid secretion in the perfused stomach of the anesthetized rat. Distension (20 cm H₂O, ○) resulted in increased output of H⁺ that was greatly reduced by hyperthermia (39°C, •). l-NAME (800 μg/kg i.c., ▪) prevented the acid-inhibitory effects of hyperthermia, an action that was abolished by administration of l-arginine (12 mg/kg, i.c., ▵). Each point represents mean ± SEM of at least six animals. Significance of difference from the control group is shown by ∗ (P < 0.05) and ∗∗ (P < 0.01), from the hyperthermia group by + (P < 0.05) and ++ (P < 0.01), and from the l-NAME-treated group by # (P < 0.05).