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. Author manuscript; available in PMC: 2009 Jan 13.
Published in final edited form as: Endocrinology. 2007 Jun 14;148(9):4318–4333. doi: 10.1210/en.2007-0161

Fig. 2.

Fig. 2

Experimental design, diet composition, and body weight responses to energy restriction and excess. The experimental timeline for this study is displayed at the top of the figure. A and B, Relative proportions of the major nutritional groups in the control (A) and HFG diet (B) applied to male and female rats for 6 months. Panels C–E are segregated according to male (left) and female (right) denoted by the gender symbols above each series of panels. This notation is retained throughout other figures in the manuscript. C, Body weights of male and female rats in the different diet groups. All of the dietary manipulations resulted in a sustained statistically significant (P < 0.05) difference in the male animals' weight, compared with control after 2 wk of implementation. The 20% CR, 40% CR, and IF females demonstrated significant (P < 0.05) weight deviation from the control group after 3 wk. The female HFG group failed to show a sustained statistical difference to control until wk 20. D and E, The amounts of food (D) and calories (E) consumed by each group of rats. Values are the mean ± sem for 15 rats in the control diet group and eight rats in each of the other diet groups.