TABLE 3.
Monoamine neurotransmitter and metabolite levels in the hippocampus of male and female rats with different dietary energy intakes
| Neurotransmitter | Male mean ± sem (pg/mg) |
Female mean ± sem (pg/mg) |
|
|---|---|---|---|
| NE | |||
| Control | 3531.4 (±127.8) | 3744.5 (±427.1) | |
| 20% CR | 3428.3 (±218.4) | 3285.9 (±143.3) | |
| 40% CR | 4479.9 (±474.7) | 4610.7 (±246.2) | |
| IF | 3579.3 (±149.4) | 3751.7 (±471.7) | |
| HFG | 3459.8 (±136.8) | 3991.1 (±638.6) | |
| DOPAC | |||
| Control | 999.6 (±10.3) | 2402.2 (±204.6) | |
| 20% CR | 1560.9 (±288.1) | 1820.2 (±188.9) | |
| 40% CR | 2565.7 (±358.1)↑a | 1974.4 (±466.6) | |
| IF | 2477.4 (±90.7) | 2809.4 (±133.9) | |
| HFG | 955.3 (±85.6) | 2092.8 (±236.8) | |
| DA | |||
| Control | 106.7 (±16.2) | 318.6 (±92.5) | |
| 20% CR | 128.3 (±40.0) | 120.0 (±43.3) | |
| 40% CR | 82.4 (±6.9) | 97.9 (±7.9)↓a | |
| IF | 71.5 (±4.7) | 163.6 (±65.6) | |
| HFG | 121.0 (±37.1) | 53.9 (±5.9)↓b | |
| 5HIAA | |||
| Control | 1863.0 (±56.9) | 2637.9 (±360.1) | |
| 20% CR | 1728.6 (±190.0) | 2047.7 (±99.9) | |
| 40% CR | 2233.9 (±139.5)↑a | 2829.1 (±333.2) | |
| IF | 1637.0 (±35.0)↓a | 2269.3 (±358.9) | |
| HFG | 1801.1 (±187.4) | 2251.8 (±313.5) | |
| 5HT | |||
| Control | 2009.7 (±118.4) | 1551.9 (±101.3) | |
| 20% CR | 1753.7 (±132.8) | 1740.6 (±94.6) | |
| 40% CR | 1870.8 (±40.0) | 2115.0 (±144.5)↑a | |
| IF | 1667.2 (±123.4) | 1977.3 (±236.3) | |
| HFG | 1531.0 (±66.6)↓a | 1728.5 (±308.6) | |
Arrows pointing upward denote an increase, whereas arrows pointing downward denote a decrease. Values are mean ± sem (n = 8–15 rats per group).
a
P < 0.05.
b
P < 0.01.