TABLE 4.
Monoamine neurotransmitter and metabolite levels in the cerebral cortex of male and female rats with different dietary energy intakes
| Neurotransmitter | Male mean ± sem (pg/mg) |
Female mean ± sem (pg/mg) |
|
|---|---|---|---|
| NE | |||
| Control | 751.2 (±59.7) | 763.3 (±19.0) | |
| 20% CR | 776.9 (±27.7) | 813.3 (±29.1) | |
| 40% CR | 814.9 (±34.9)↑a | 879.2 (±34.6) | |
| IF | 844.3 (±61.8) | 798.0 (±38.9) | |
| HFG | 819.0 (±21.6)↑a | 866.6 (±29.2) | |
| DOPAC | |||
| Control | 141.4 (±31.9) | 135.8 (±25.0) | |
| 20% CR | 173.1 (±25.9) | 155.4 (±29.3) | |
| 40% CR | 145.7 (±26.2) | 151.8 (±28.6) | |
| IF | 174.2 (±34.3) | 191.3 (±31.6) | |
| HFG | 175.1 (±17.7) | 183.7 (±30.2) | |
| DA | |||
| Control | 598.1 (±42.9) | 623.1 (±94.3) | |
| 20% CR | 656.9 (±82.1) | 575.6 (±66.4) | |
| 40% CR | 604.4 (±89.6) | 727.9 (±68.2) | |
| IF | 595.6 (±81.5) | 601.9 (±58.9) | |
| HFG | 567.8 (±55.2) | 735.8 (±75.6) | |
| 5HIAA | |||
| Control | 237.4 (±16.9) | 226.8 (±17.3) | |
| 20% CR | 194.8 (±16.0)↓a | 226.1 (±11.5) | |
| 40% CR | 220.7 (±23.0) | 262.4 (±13.3) | |
| IF | 179.1 (±23.5)↓a | 173.6 (±13.8)↓a | |
| HFG | 185.6 (±24.2) | 187.8 (±11.5)↓a | |
| 5HT | |||
| Control | 400.4 (±12.7) | 380.6 (±22.1) | |
| 20% CR | 368.2 (±12.5) | 373.8 (±25.2) | |
| 40% CR | 358.7 (±18.8) | 406.9 (±18.5) | |
| IF | 343.3 (±29.5) | 354.7 (±28.9) | |
| HFG | 353.9 (±16.2)↓a | 375.6 (±14.1) | |
| HVA | |||
| Control | 47.9 (±5.8) | 46.6 (±3.7) | |
| 20% CR | 45.4 (±3.7) | 44.2 (±3.2) | |
| 40% CR | 45.2 (±5.8) | 57.0 (±6.4) | |
| IF | 37.6 (±4.4) | 41.7 (±5.8) | |
| HFG | 32.4 (±4.2)↓a | 45.0 (±5.7) | |
Arrows pointing upward denote an increase, whereas arrows pointing downward denote a decrease. Values are mean ± sem (n = 8–15 rats/group).
a
P < 0.05.