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Platelet lysis requires pore formation. Shown are aggregometer readings for platelets treated with prepore locked mutants of LLY (a), ILY (b), and PFO (c) in their oxidized (LLYppl-ox, ILYppl-ox, and PFOppl-ox) and reduced forms (LLYppl-red, ILYppl-red, and PFOppl-red). Conditions were similar to those in Figure 3a; all toxins were added at approximately 70 nM. The reduction of the disulfide allows each prepore-locked mutant to convert to the pore complex.
