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. Author manuscript; available in PMC: 2009 Jan 13.
Published in final edited form as: Biochemistry. 2008 Jun 14;47(27):7097–7107. doi: 10.1021/bi8005835

Figure 7.

Figure 7

The glycan-binding domain of LLY modulates pore-forming activity. LLY-dependent calcein release from calcein-loaded PRP was measured by flow cytometry. (a) LLY-dependent calcein release from platelets of high (donor 1) and low responding donors (donor 3) which were preincubated without (solid lines) or with (dashed lines) LLYLec (56 nM). No change is observed with LLYLec alone (not shown). (b) Calcein release from platelets treated with LLY or LLYCDC. (c) Same as the experiments shown in (a) with donor 1 platelets except that LLYCDC was substituted for LLY.