. Author manuscript; available in PMC: 2009 Jan 13.

Published in final edited form as: J Med Chem. 2006 Jun 29;49(13):3982–3989. doi: 10.1021/jm050885v

Table 2.

Structures of alkylating agents and thiols used for the synthesis of BHMT inhibitors. The yields are reported after HPLC purification. For details see Experimental. The structures of products are shown in Table 1.

		Reaction Product	Yield (%)
29	5	2	31^a, 76^c
30	5	8	20^a
31	5	9	27^a
29	6	12	36^a
7	32	13	36^b
7	33	14	28^b
7	34	15	19^b
35	5	16	15^a
36	5	17	69^a
37	5	18	2^a
38	5	19	53^a
39	5	20	21^a
40	5	22	46^a
41	5	23	8^a
42	5	24	52^a

Product was prepared according to the Method A.

Product was prepared according to the Method B.

Product was prepared according to Method C.