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. 2003 Nov;69(11):6418–6426. doi: 10.1128/AEM.69.11.6418-6426.2003

FIG. 4.

FIG. 4.

Pathway from HAVN to AVR clarified in this study. HAVN is converted to OAVN by HAVN dehydrogenase, which requires NAD, but not NADP, for its activity. OAVN is then converted to AVR by a novel OAVN cyclase enzyme.