Table 3. List of 10 most statistically significant canonical pathways maps represented by detectable analytes in normal aqueous samples.

Number	Key network objects	GO Processes	p value	zScore	gScore
1	A2M, Kallikrein 3 (PSA), Alpha 1-antitrypsin, VEGF-A, PAI1	organ development (61.4%; 4.075e−10), response to wounding (36.4%; 4.455e−10), response to external stimulus (43.2%; 4.572e−10), cell proliferation (50.0%; 5.309e−10), positive regulation of cell proliferation (31.8%; 6.986e−10)	2.36e−31	61.1	61.1
2	Stromelysin-1, CCL2, TIMP1, MIP-1-beta, Alpha 1-antitrypsin	response to external stimulus (47.8%; 1.468e−12), response to wounding (37.0%; 9.322e−11), wound healing (23.9%; 1.290e−10), blood coagulation (15.2%; 3.146e−07), coagulation (15.2%; 3.914e−07)	8.46e−29	57.4	57.4
3	VEGF-A, Endothelin-1, PAI1, Stromelysin-1, CD40(TNFRSF5)	response to stimulus (75.5%; 5.440e−14), response to stress (55.1%; 3.472e−13), protein kinase cascade (40.8%; 3.739e−13), response to external stimulus (46.9%; 7.466e−13), cell surface receptor linked signal transduction (57.1%; 1.494e−12)	1.14e−28	56.8	56.8
4	F3, Beta-2-glycoprotein I (APOH), VCAM1, MIP-1-beta, CCL2	cell adhesion (53.2%; 8.293e−19), biological adhesion (53.2%; 8.293e−19), response to wounding (51.1%; 1.218e−18), localization of cell (51.1%; 5.939e−17), cell motility (51.1%; 5.939e−17)	1.14e−28	56.8	58.1
5	CD40(TNFRSF5), CRP, G-CSF, F3, APCS	immune system process (57.1%; 2.349e−16), immune response (44.9%; 1.384e−14), response to stimulus (73.5%; 4.961e−13), defense response (40.8%; 6.493e−12), adaptive immune response (20.4%; 1.681e−10)	1.14e−28	56.8	56.8
6	APOA1, PPAP, Adiponectin, APOC3, MIP-1-alpha	sterol transport (15.2%; 3.842e−08), cholesterol transport (15.2%; 3.842e−08), triacylglycerol metabolic process (12.1%; 1.119e−06), lipid transport (15.2%; 1.661e−06), response to stimulus (63.6%; 1.781e−06)	4.46e−27	57.2	57.2
7	CCL2, CCL5, Eotaxin, MIP-1-beta, MIP-1-alpha	cytokine and chemokine mediated signaling pathway (25.5%; 4.692e−17), locomotory behavior (38.3%; 1.594e−16), chemotaxis (31.9%; 5.793e−16), taxis (31.9%; 5.793e−16), response to external stimulus (53.2%; 1.704e−15)	1.82e−23	48	68
8	A2M, Endothelin-1, CCL5, IL-6, MIP-1-beta	response to stimulus (75.5%; 5.440e−14), response to external stimulus (49.0%; 7.073e−14), regulation of protein metabolic process (34.7%; 5.809e−13), defense response (42.9%; 6.006e−13), inflammatory response (34.7%; 1.171e−12)	5.95e−21	43.6	43.6
9	Beta-2-microglobulin, APOA1, TR2(TNFRSF14), VCAM1, GSTM1	response to stimulus (75.0%; 1.873e−11), positive regulation of transferase activity (27.5%; 2.304e−10), positive regulation of kinase activity (25.0%; 3.531e−09), positive regulation of catalytic activity (27.5%; 2.827e−08), regulation of transferase activity (27.5%; 3.249e−08)	4.09e−16	34.9	34.9
10	PPAP, Thyroxine-binding globulin, Adiponectin, Epo, APOLPA	protein kinase cascade (34.3%; 2.065e−07), intracellular signaling cascade (48.6%; 2.204e−07), positive regulation of kinase activity (22.9%; 2.930e−07), positive regulation of transferase activity (22.9%; 3.458e−07), regulation of cell differentiation (25.7%; 3.570e−07)	2.29e−14	33.3	33.3

Network objects represent the fraction of the number of genes from input list against total number of genes from MetaCore database for respective network. These included cell adhesion pathways, cytokine signaling pathways, and pathways for immune system processes.