Table 6. Comparison between processes in diabetic and non-diabetic aqueous humor.
| Number | Processes | Size | Target | Pathways | p value | zScore |
|---|---|---|---|---|---|---|
|
Common | ||||||
| 1 |
Locomotory behavior (42.6%), G-protein coupled receptor protein signaling pathway (51.1%), cell surface receptor linked signal transduction (66.0%) |
50 |
13 |
10 |
8.58e−29 |
57.35 |
| 2 |
Response to external stimulus (56.2%), response to wounding (47.9%), response to stimulus (79.2%) |
50 |
14 |
1 |
1.73e−31 |
61.78 |
| 3 |
Lipid transport (29.4%), sterol transport (23.5%), cholesterol transport (23.5%) |
50 |
12 |
0 |
3.44e−27 |
57.78 |
| 4 |
Immune system process (54.0%), organ development (68.0%), response to stimulus (74.0%) |
50 |
13 |
0 |
8.58e−29 |
57.35 |
| 5 |
Response to stimulus (75.0%), response to wounding (40.9%), response to external stimulus (47.7%) |
50 |
7 |
6 |
4.60e−14 |
31.76 |
|
Unique for Diabetes Samples | ||||||
| 1 |
Response to external stimulus (50.0%), response to wounding (41.3%), cell surface receptor linked signal transduction (58.7%) |
50 |
4 |
0 |
1.33e−11 |
51.55 |
| 2 |
Taxis (100.0%), chemotaxis (100.0%), locomotory behavior (100.0%) |
5 |
1 |
0 |
6.01e−04 |
40.77 |
|
Unique for Normal Samples | ||||||
| 1 |
Response to wounding (37.2%), response to stimulus (69.8%), intracellular signaling cascade (51.2%) |
50 |
8 |
0 |
1.68e−21 |
67.49 |
| 2 |
Response to external stimulus (53.8%), response to wounding (46.2%), cell surface receptor linked signal transduction (64.1%) |
44 |
5 |
0 |
8.36e−13 |
44.93 |
| 3 | Cellular di-, tri-valent inorganic cation homeostasis (100.0%), di-, tri-valent inorganic cation homeostasis (100.0%), cellular cation homeostasis (100.0%) | 27 | 2 | 0 | 3.28e−06 | 37.72 |
The table lists the top related processes, the total number of genes in the network (Size), the number of genes in the network from the input list (Target) and the number of canonical pathways used to build the network (pathways). The comparison of diabetic and non-diabetic samples shows several processes listed under unique to diabetes and unique to normal samples changed in the diabetic and non-diabetic samples.