Table 1.
Participant Characteristics at EDIC Study Baseline
| Characteristic | Originai DCCT Treatment Group | P Value* | |
|---|---|---|---|
| Intensive (n=676) |
Conventional (n=673) |
||
| Age, mean (SD), Y | 34 (7) | 33 (7) | .11 |
| Women, No. (%) | 330 (49) | 313(46) | .40 |
| Diabetes duration, mean (SD), y | 12 (5) | 12(5) | >.99 |
| HbAlc, mean (SD), % | 7,4 (1,1) | 9.1(1.6) | <.001 |
| Body mass index, mean (SD)† | 26.5(4) | 25.0(3) | >.001 |
| Smoking, No. (%) | 155(23) | 145(22) | .54 |
| LDL-C, mean (SD), mg/dL | 113(27) | 115(32) | .39 |
| Albumin excretion rate‡ Median (IQR), mg/24 h |
8.6 (5.8-14.4) | 10.1 (5.8-20.2) | <.001 |
| >28 μg/min, No. (%) | 50(7.4) | 87(12.9) | <.001 |
| >208 μg/min, No. (%) | 10(1.5) | 20(3.0) | .06 |
| Serum creatinine, mean (SD),mg/dl | 0.85(0.17) | 0.84(0.15) | .12 |
| GFR by 125I-iothalamate clearance, mean (SD),mL/min per 1.73 m2 |
125(20) | 126(21) | .26 |
| <70 mL/min per 1.73 m2, No.(%) | 2(0.4) | 3(0.6) | .68 |
| Standard creatinine clearance, mean (SD), mL/min per 1.73 m2 |
122(26) | 122(26) | .57 |
| <70 mL/min per 1.73 m2, No. (%) | 10(1.5) | 10(1.5) | .99 |
| Blood pressure, mm Hg >140/90, confirmed, No. (%) |
74(11) | 71(11) | .81 |
| >130/80, unconfirmed, No. (%) | 260(39) | 242(36) | .35 |
| Arterial pressure, mean (SD), mm Hg§ | 89(9) | 88(9) | .26 |
| Heart rate, mean (SD),beatdmin | 75(10) | 75(10) | .19 |
Abbreviations: DCCT, Diabetes Control and Complications Triaf; EDIC, Epidemiology of Diabetes Interventions and Complications; GFR, glomerular filtration rate; HbAlc, glycosylated hemoglobin; IQR, interquartile range; LDL-C, lowdensity lipoprotein cholesterol.
SI conversion factors: To convert LDL-C to mmoVL, multiply mg/dL values by 0.0259; to convert serum creatinine to μmoVL, multiply mg/o’L values by 88.4; to convert GFR and standard creatinine clearance to mL/s, multiply mL/min values by 0.0167.
From Wilcoxon rank-scam test (continuous variables) and χ2 or Fisher exact test (categorical variables).
Calculated as weight in kilograms divided by the square of height in meters.
Based on 4-how collection of urine.
Mean arterial pressure = 2/3 diastolic pressure + 1/3 systdic pressure.