Figure 6. hAtx1-82Q expression in glial cell lineage induces pathological change in the central nervous system.

(A) Double-staining with anti-human Atx1 (H21) and anti-repo antibodies shows co-localization of mutant hAtx1 and repo proteins in glial cells of repo; hATX1-82Q pupae (arrowhead). A small part cells expressed only repo or hAtx1 protein (arrow). The former would non-expressors and the latter would be ghost cells with hAtx1 inclusions. (B) Immunohistochemistry with anti-repo and anti-elav antibodies showing glial cells and neurons, respectively. The right higher magnifications show photoreceptor cells in the retina, which were remarkably reduced in repo; hATX1-82Q pupae.