Figure 2.

Comparison of the nocturnin amino acid sequence with the yeast CCR4 sequence. (A) The last 291 amino acids of the nocturnin sequence (Top) are aligned with the last 335 amino acids of the CCR4 sequence (ref. 32; bottom and underlined) as determined by blast search algorithms. Positions of identical amino acids are designated by double dots (:), conservative amino acid changes are designated by single dots (.). Dashes within the sequence are gaps inserted for maximal alignment. The nocturnin sequence shown begins with amino acid number 98 and CCR4 sequence begins with amino acid number 606. (B) Diagrammatic representation of nocturnin and CCR4 alignment. Rectangular boxes represent the amino acid sequence with the N termini on the left and the C termini on the right. The regions of similarity between the two proteins are marked by the diagonal lines. The position of the other defined domains or motifs are marked (33).