Supplementary Table 2.
Sensitivity of ΔA in equations (10)–(12) in cancer cells under heat shock.
ΔAi,j | p53 | ARF | MDM2 | p21 | cdk2 | Rb | MAPK14 | Wip-1 | Siah-1 | β-catenin | PTEN | PIP3 | AKT2 | CCNG1 | PP2A | p73 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
α1,1 | 62.91 | 104.48 | 93.86 | 54.28 | 151.94 | 75.73 | 72.25 | 96.55 | 81.12 | 68.16 | 93.92 | 84.44 | 46.21 | 73.95 | 73.92 | 93.93 |
α1,3 | 54.36 | 90.28 | 81.10 | 46.91 | 131.29 | 65.44 | 62.43 | 83.43 | 70.09 | 58.90 | 81.16 | 72.96 | 39.93 | 63.90 | 63.87 | 81.16 |
α1,6 | 477.88 | 793.73 | 713.02 | 412.38 | 1154.27 | 575.33 | 548.86 | 733.47 | 616.23 | 517.79 | 713.51 | 641.44 | 351.03 | 561.78 | 561.52 | 713.54 |
α1,7 | 91.33 | 151.70 | 136.27 | 78.82 | 220.61 | 109.96 | 104.90 | 140.18 | 117.77 | 98.96 | 136.37 | 122.59 | 67.09 | 107.37 | 107.32 | 136.37 |
α2,1 | 50.17 | 83.33 | 74.86 | 43.30 | 121.18 | 60.40 | 57.62 | 77.00 | 64.70 | 54.36 | 74.91 | 67.34 | 36.85 | 58.98 | 58.95 | 74.91 |
α2,2 | 40.09 | 66.58 | 59.81 | 34.59 | 96.83 | 48.26 | 46.04 | 61.53 | 51.69 | 43.43 | 59.85 | 53.81 | 29.45 | 47.12 | 47.10 | 59.86 |
α2,10 | 55.29 | 91.84 | 82.50 | 47.71 | 133.55 | 66.57 | 63.50 | 84.86 | 71.30 | 59.91 | 82.55 | 74.22 | 40.62 | 65.00 | 64.97 | 82.56 |
α3,1 | 128.60 | 213.54 | 191.83 | 111.45 | 310.53 | 154.80 | 147.68 | 197.33 | 165.80 | 139.32 | 191.96 | 172.58 | 94.61 | 151.15 | 151.08 | 191.97 |
α3,2 | 46.96 | 77.99 | 70.05 | 41.07 | 113.47 | 56.52 | 53.92 | 72.06 | 60.54 | 50.87 | 70.10 | 63.01 | 34.65 | 55.18 | 55.16 | 70.10 |
α3,3 | 55.65 | 92.26 | 82.89 | 48.62 | 134.14 | 66.93 | 63.85 | 85.27 | 71.67 | 60.25 | 82.95 | 74.59 | 41.12 | 65.35 | 65.32 | 82.95 |
α3,5 | 71.99 | 119.40 | 107.27 | 62.76 | 173.61 | 86.60 | 82.62 | 110.35 | 92.73 | 77.96 | 107.34 | 96.51 | 53.14 | 84.55 | 84.52 | 107.34 |
α3,6 | 50.17 | 83.26 | 74.79 | 43.90 | 121.13 | 60.36 | 57.58 | 76.94 | 64.65 | 54.33 | 74.84 | 67.28 | 37.08 | 58.93 | 58.91 | 74.84 |
α3,13 | 61.08 | 101.34 | 91.04 | 53.30 | 147.35 | 73.49 | 70.11 | 93.65 | 78.70 | 66.15 | 91.10 | 81.91 | 45.07 | 71.75 | 71.72 | 91.10 |
α3,15 | 60.96 | 101.08 | 90.81 | 53.18 | 146.97 | 73.32 | 69.95 | 93.42 | 78.52 | 66.01 | 90.88 | 81.71 | 45.01 | 71.59 | 71.56 | 90.88 |
α3,16 | 95.58 | 158.83 | 142.65 | 83.07 | 231.11 | 115.08 | 109.77 | 146.76 | 123.27 | 103.55 | 142.75 | 128.31 | 70.37 | 112.35 | 112.31 | 142.76 |
α4,1 | 44.69 | 74.23 | 66.68 | 38.57 | 107.95 | 53.81 | 51.33 | 68.60 | 57.63 | 48.42 | 66.73 | 59.99 | 32.83 | 52.54 | 52.51 | 66.73 |
α4,4 | 58.94 | 97.90 | 87.94 | 50.86 | 142.37 | 70.96 | 67.70 | 90.47 | 76.01 | 63.86 | 88.00 | 79.12 | 43.30 | 69.29 | 69.26 | 88.01 |
α5,4 | 67.07 | 111.40 | 100.07 | 57.88 | 162.01 | 80.75 | 77.03 | 102.94 | 86.49 | 72.67 | 100.14 | 90.03 | 49.27 | 78.85 | 78.81 | 100.15 |
α5,5 | 74.10 | 123.07 | 110.56 | 63.94 | 178.98 | 89.21 | 85.10 | 113.73 | 95.55 | 80.29 | 110.63 | 99.46 | 54.43 | 87.11 | 87.07 | 110.64 |
α6,5 | 128.80 | 213.93 | 192.18 | 111.15 | 311.10 | 155.06 | 147.93 | 197.69 | 166.09 | 139.56 | 192.31 | 172.88 | 94.61 | 151.41 | 151.34 | 192.32 |
α6,6 | 72.60 | 120.59 | 108.33 | 62.65 | 175.36 | 87.41 | 83.39 | 111.43 | 93.62 | 78.67 | 108.40 | 97.45 | 53.33 | 85.35 | 85.31 | 108.41 |
α7,7 | 76.58 | 127.19 | 114.26 | 66.08 | 184.96 | 92.19 | 87.95 | 117.53 | 98.75 | 82.97 | 114.34 | 102.79 | 56.25 | 90.02 | 89.98 | 114.34 |
α7,8 | 65.35 | 108.54 | 97.51 | 56.39 | 157.85 | 78.68 | 75.06 | 100.30 | 84.27 | 70.81 | 97.57 | 87.72 | 48.00 | 76.82 | 76.79 | 97.58 |
α8,1 | 64.75 | 107.54 | 96.61 | 55.87 | 156.39 | 77.95 | 74.36 | 99.38 | 83.49 | 70.15 | 96.67 | 86.91 | 47.56 | 76.12 | 76.08 | 96.68 |
α8,8 | 34.85 | 57.88 | 51.99 | 30.07 | 84.17 | 41.95 | 40.02 | 53.48 | 44.93 | 37.76 | 52.03 | 46.77 | 25.60 | 40.96 | 40.94 | 52.03 |
α9,1 | 49.96 | 82.98 | 74.54 | 43.11 | 120.67 | 60.15 | 57.38 | 76.68 | 64.42 | 54.13 | 74.59 | 67.06 | 36.70 | 58.73 | 58.70 | 74.60 |
α9,9 | 56.64 | 94.08 | 84.52 | 48.88 | 136.82 | 68.20 | 65.06 | 86.94 | 73.04 | 61.38 | 84.58 | 76.03 | 41.61 | 66.59 | 66.56 | 84.58 |
α10,9 | 60.20 | 99.98 | 89.81 | 51.95 | 145.40 | 72.47 | 69.14 | 92.39 | 77.62 | 65.22 | 89.88 | 80.80 | 44.22 | 70.76 | 70.73 | 89.88 |
α10,10 | 44.18 | 73.38 | 65.91 | 38.12 | 106.70 | 53.19 | 50.74 | 67.80 | 56.97 | 47.87 | 65.96 | 59.30 | 32.45 | 51.93 | 51.91 | 65.96 |
α11,1 | 49.81 | 82.73 | 74.31 | 42.98 | 120.30 | 59.96 | 57.20 | 76.45 | 64.23 | 53.97 | 74.37 | 66.85 | 36.59 | 58.55 | 58.52 | 74.37 |
α11,11 | 153.19 | 254.45 | 228.57 | 132.20 | 370.02 | 184.43 | 175.95 | 235.13 | 197.54 | 165.99 | 228.73 | 205.63 | 112.53 | 180.09 | 180.01 | 228.74 |
α12,11 | 726.80 | 1207.18 | 1084.42 | 627.19 | 1755.51 | 875.01 | 834.75 | 1115.52 | 937.21 | 787.50 | 1085.17 | 975.56 | 533.88 | 854.41 | 854.01 | 1085.22 |
α12,12 | 59.19 | 98.30 | 88.31 | 51.08 | 142.95 | 71.25 | 67.98 | 90.84 | 76.32 | 64.13 | 88.37 | 79.44 | 43.48 | 69.58 | 69.54 | 88.37 |
α13,12 | 46.13 | 76.62 | 68.83 | 39.81 | 111.42 | 55.53 | 52.98 | 70.80 | 59.48 | 49.98 | 68.87 | 61.92 | 33.88 | 54.23 | 54.20 | 68.88 |
α13,13 | 38.01 | 63.14 | 56.72 | 32.80 | 91.82 | 45.77 | 43.66 | 58.35 | 49.02 | 41.19 | 56.76 | 51.03 | 27.92 | 44.69 | 44.67 | 56.76 |
α14,1 | 79.15 | 131.46 | 118.09 | 68.30 | 191.17 | 95.28 | 90.90 | 121.48 | 102.06 | 85.76 | 118.17 | 106.23 | 58.14 | 93.04 | 93.00 | 118.18 |
α14,14 | 44.06 | 73.18 | 65.74 | 38.02 | 106.42 | 53.04 | 50.60 | 67.63 | 56.82 | 47.74 | 65.79 | 59.14 | 32.37 | 51.80 | 51.77 | 65.79 |
α15,14 | 45.47 | 75.52 | 67.84 | 39.24 | 109.82 | 54.74 | 52.22 | 69.78 | 58.63 | 49.26 | 67.89 | 61.03 | 33.40 | 53.45 | 53.42 | 67.89 |
α15,15 | 56.83 | 94.39 | 84.79 | 49.04 | 137.27 | 68.42 | 65.27 | 87.22 | 73.28 | 61.58 | 84.85 | 76.28 | 41.75 | 66.81 | 66.78 | 84.85 |
α16,1 | 96.68 | 160.58 | 144.25 | 83.43 | 233.53 | 116.39 | 111.04 | 148.39 | 124.67 | 104.75 | 144.35 | 129.77 | 71.02 | 113.65 | 113.60 | 144.36 |
α16,3 | 50.50 | 83.87 | 75.34 | 43.58 | 121.97 | 60.79 | 58.00 | 77.50 | 65.12 | 54.71 | 75.40 | 67.78 | 37.09 | 59.36 | 59.33 | 75.40 |
α16,14 | 47.29 | 78.54 | 70.56 | 40.81 | 114.22 | 56.93 | 54.31 | 72.58 | 60.98 | 51.24 | 70.60 | 63.47 | 34.74 | 55.59 | 55.56 | 70.61 |
α16,16 | 88.04 | 146.23 | 131.36 | 75.97 | 212.65 | 105.99 | 101.11 | 135.12 | 113.53 | 95.39 | 131.45 | 118.17 | 64.67 | 103.50 | 103.45 | 131.45 |