Table 1.
Expression of sodium channel α-subunit mRNAs SNS and III in control and axotomized DRG neurons in situ
| mRNA | Tissue | % small neurons (<30-μm
diameter)
|
% large neurons (>30-μm diameter)
|
||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| 0 | + | ++ | +++ | (n) | 0 | + | ++ | +++ | (n) | ||
| SNS | Control | 3.1 | 13.2 | 42.2 | 41.5 | (258) | 44.2 | 33.7 | 19.6 | 2.5 | (163) |
| SNS | Axotomized | 40.4 | 31.6 | 23.6 | 4.4 | (225) | 58.3 | 25.9 | 14.4 | 1.4 | (139) |
| III | Control | 44.4 | 50.0 | 5.6 | 0.0 | (144) | 63.3 | 32.5 | 4.2 | 0.0 | (121) |
| III | Axotomized | 29.1 | 38.3 | 23.3 | 9.2 | (120) | 27.5 | 46.1 | 17.6 | 7.8 | (102) |
Numbers are percentage of DRG neurons that express 0, undetectable; +, marginal/low; ++, moderate; and +++, high levels of hybridization signal for each size class. Numbers in parentheses, number of DRG neurons for each size class scored for expression of sodium channel mRNA from at least two separate experiments.