TABLE 1.
Reactivities of MAbs against parvoviruses by HI assay
| Antigenic type | Isolate | Reactivity with the following MAb (isotype)a:
|
|||
|---|---|---|---|---|---|
| 2G5 (IgG3) | 21C3 (IgG1) | 19D7 (IgG2a) | 20G4 (IgG2a) | ||
| FPLV | TU-1 | <1,000 | <100 | 32,000 | <100 |
| FPLV | No. 311 | <1,000 | <100 | 64,000 | <100 |
| FPLV | V142 | <1,000 | <100 | 32,000 | <100 |
| MEV-1 | Abashiri | <1,000 | <100 | 16,000 | <100 |
| MEV-2 | M-1 | <1,000 | <100 | 64,000 | <100 |
| CPV-2 | Cp49 | <1,000 | <100 | 32,000 | <100 |
| CPV-2 | Cp82031 | <1,000 | <100 | 32,000 | <100 |
| CPV-2a | 97-003 | 64,000 | <100 | 32,000 | 3,200 |
| CPV-2a | V220 | 64,000 | <100 | 32,000 | 6,400 |
| CPV-2b | 97-008 | 64,000 | 12,800 | 128,000 | 1,600 |
| CPV-2b | V123 | 64,000 | 6,400 | 256,000 | 6,400 |
| LCPV-2c(a)b | V139 | 128,000 | <100 | 32,000 | 512,000 |
| LCPV-2c(a) | V140 | 128,000 | <100 | 32,000 | 512,000 |
| LCPV-2c(b) | V203 | 64,000 | 3,200 | 128,000 | 128,000 |
a
The specificities of the MAbs for the antigenic types were as follows: MAb 2G5, CPV-2a, CPV-2b, CPV-2c(a), and CPV-2c(b); MAb 21C3, CPV-2b and CPV-2c(b); MAb 19D7, FPLV, MEV-1, MEV-2, CPV-2, CPV-2a, CPV-2b, CPV-2c(a), and CPV-2c(b); MAb 20G4, CPV-2a and CPV-2b < CPV-2c. IgG3, immunoglobulin G3.
b
LCPV, leopard cat CPV.