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Within-tissue variability of levels of IL-1β (a), IL-6 (b), IL-8 (c), and MMP-3 (d) in synovial tissue extracts from 5 RA patients expressed as amounts per milligram of total protein. Three different synovial fragments from each tissue were extracted with 0.1% Igepal and diluted 1:10 before ELISA. Individual data points (×) are shown together with the means ± standard deviations (wide bar and brackets) on a logarithmic scale.
