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Within-tissue variability of biomarker concentrations in RA synovial extractsa
| Biomarker | Average CV (%) (range), normalized by wet wt | Average CV (%) (range), normalized by total extracted protein content |
|---|---|---|
| IL-1β | 66 (39-124) | 62 (37-113) |
| IL-6 | 64 (9-134) | 62 (13-124) |
| IL-8 | 37 (4-89) | 35 (15-76) |
| MMP-3 | 54 (12-88) | 49 (21-72) |
Within-tissue CVs were calculated for extracts of three individual tissue fragments from each of 5 RA synovia.
