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. Author manuscript; available in PMC: 2009 Jun 26.
Published in final edited form as: J Med Chem. 2008 Jun 4;51(12):3649–3653. doi: 10.1021/jm8001026

Scheme 1. Synthesis of the triazolopyrimidine-based seriesa.

Scheme 1

aReagents and conditions: (i) AcOH, 3.5-8 h, reflux, 40-58%; (ii) POCl3, 30-60 min., reflux, 43-65%; (iii) R2R3NH, EtOH, 8-15 h, rt, 80-87%.