Table 1.
Demographic Data by Clinical Diagnosis Closest to Death (N = 93)
| Cognitively Normal (n = 15) | CIND (n = 15) | SIVD (n = 11) | pAD (n = 32) | Mixed AD/SIVD (n = 20) | Pa | |
|---|---|---|---|---|---|---|
| Mean age at death, yr (SD) | 84.2 (6.5)b | 82.3 (5.6) | 84.9 (8.4) | 82 (8.3) | 85.6 (6.1) | 0.41 |
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| Mean education, yr (SD) | 13.3 (2.5) | 15.1 (3) | 13.3 (2.8) | 14.9 (3.6) | 12.3 (2.7) | 0.02 |
| Cortical gray matter, % (SD) | 38.5 (2.2) | 35.4 (3.6) | 34.2 (2.8) | 35 (2.4) | 34.3 (4.3) | 0.001 |
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| Hippocampal volume, % (SD) | 0.3 (0.1) | 0.3 (0) | 0.2 (0) | 0.2 (0) | 0.2 (0.1) | <0.0001 |
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| White matter hyperintensities, % (SD) | 1.1 (1) | 2.2 (1.9) | 3.5 (2.9) | 0.9 (1) | 2.7 (2.3) | 0.0002 |
| Number of lacunes (SD) | 0.5 (0.7) | 3.1 (3) | 2.9 (2.9) | 0.9 (1.5) | 1.8 (2.5) | 0.003 |
| Mean time from last MRI to death, yr (range) | 3.3 (0.8–8.3) | 1.5 (0.2–3.1) | 2.7 (0.7–6.6) | 3.3 (0.5–7.8) | 2.2 (0.3–8.7) | 0.02 |
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| Mean global cognitive score (SD) | 94.4 (16.2) | 91.1 (17.9) | 49.9 (17.9) | 44.9 (19) | 51.6 (18.2) | <0.0001 |
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| Mean last MMSE score (SD) | 28.4 (1.4) | 28.1 (2.1) | 17.6 (6.1) | 11.9 (8.4) | 12.8 (6.8) | <0.0001 |
| Mean time from last neuropsychological testing to death, yr (SD) | 1.7 (2) | 0.9 (0.8) | 2.1 (2) | 2.2 (1.6) | 2.1 (1.9) | 0.19 |
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| Sex, n (%)
| ||||||
| Male | 6 (40) | 9 (60) | 5 (45) | 20 (63) | 12 (60) | 0.61 |
| Female | 9 (60) | 6 (40) | 6 (55) | 12 (38) | 8 (40) | |
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| Race, n (%) | ||||||
| White | 14 (93) | 14 (93) | 8 (73) | 31 (97) | 15 (75) | 0.09 |
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| Hispanic | 0 (0) | 0 (0) | 0 (0) | 1 (3) | 1 (5) | |
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| Black | 0 (0) | 1 (7) | 1 (9) | 0 (0) | 2 (10) | |
| Asian | 1 (7) | 0 (0) | 2 (18) | 0 (0) | 2 (10) | |
a
p value from analysis of variance for continuous variables, from Fisher’s exact test for categoric variables.
CIND = cognitive impairment, no dementia; SIVD = subcortical ischemic vascular dementia; pAD = probable or possible Alzheimer’s disease; AD = Alzheimer’s disease; SD = standard deviation; MRI = magnetic resonance imaging; MMSE = Mini-Mental State Examination.