Table 2.

Final Multivariate Linear Regression Models Evaluating the Association between Neuropathological Variables and Magnetic Resonance Imaging Measures at Visit Closest to Death (N = 93)

Dependent Variable	Independent Variable	β	SE	p	r2
Cortical gray matter volume	Intercept	38.72	0.92	<0.0001	0.25
	AD-PATH	−0.47	0.17	0.006
	ARTERIO	−0.6	0.24	0.02
	SUBCORTICAL INF	−0.05	0.03	0.045
Hippocampal volumea	Intercept	0.27	0.01	<0.0001	0.33
	AD-PATH	−0.01	0.003	<0.0001
	HS	−0.02	0.006	0.009
White matter hyperintensitiesb	Intercept	−0.01	0.09	0.89	0.32
	WMP	0.02	0.003	<0.0001
	Age at death	0.02	0.007	0.01

All models were adjusted for time from last magnetic resonance imaging (MRI) scan to death. Units of all MRI variables are percentage intracranial volume.

^aAdjusted for sex in the final model.

^bWhite matter hyperintensities were log transformed.

SE = standard error; AD-PATH = Alzheimer’s disease pathology (0–6); ARTERIO = sum of atherosclerosis and arteriolosclerosis scores (0–6); SUBCORTICAL INF = subcortical infarct scores (0–100); HS = hippocampal sclerosis (0–4); WMP = white matter pathology score (0–100).