Table 2.
Comparison of mean CIMT and prevalence of carotid lesions among HIV-infected and -uninfected participants in women (Women's Interagency HIV Study) and men (Multicenter AIDS Cohort Study)
| |
|
|
Without Metabolic Risk Factor Adjustment(1) |
With Metabolic Risk Factor Adjustment(2) |
||
|---|---|---|---|---|---|---|
| Carotid intima-media thickness (C IMT) | ||||||
| N | Mean C IMT (μm) | Adjusted Mean Difference in C IMT (95% CI) | P-value | Adjusted Mean Difference in C IMT (95% CI) | P-value | |
| Women | ||||||
| HIV-uninfected | 496 | 716 | R E F | R E F | ||
| HIV-infected | 1,231 | 722 | −12 (−23, −2) | 0.02 | −7 (−18, 3) | 0.17 |
| Men | ||||||
| HIV-uninfected | 325 | 771 | R E F | R E F | ||
| HIV-infected | 600 | 750 | −11 (−30, 9) | 0.27 | −7 (−27, 12) | 0.47 |
| Carotid lesions | ||||||
|---|---|---|---|---|---|---|
| N | Prevalence of Lesions (%) | Adjusted Prevalence Ratio (95% CI) | P-value | Adjusted Prevalence Ratio (95% CI) | P-value | |
| Women | ||||||
| HIV-uninfected | 496 | 6% | R E F | R E F | ||
| HIV-infected | 1,231 | 10% | 1.24 (0.83, 1.85) | 0.29 | 1.13 (0.74, 1.72) | 0.57 |
| Men | ||||||
| HIV-uninfected | 325 | 30% | R E F | |||
| HIV-infected | 600 | 28% | 1.23 (0.94, 1.62) | 0.13 | 1.21 (0.91, 1.60) | 0.20 |
(1)
Adjusted for age, race, education, income level, family history of myocardial infarction, current smoking, alcohol consumption, opiate use, history of injection drug use, and study site
(2)
In addition to factors listed for (1), also adjusted for history of diabetes, use of cholesterol medications, BMI, systolic blood pressure, LDL and HDL cholesterol