Table 3.
Down-regulated genes in smokers (Limited to 25)
| Entrez ID | Symbol | mean Ratio | P_IDs | Gene Name | Gene Function | (Potential role in Development |
|---|---|---|---|---|---|---|
| 200315 | APOBEC3A | −2.78 | 210873_x_at | apolipoprotein B mRNA editing enzyme | Cell regulation | BI(32) |
| 4680 | CEACAM6 | −2.72 | 211657_at | carcinoembryonic antigen-related CAM 6 | Tissue architecture | CG(48) |
| 2568 | GABRP | −2.53 | 205044_at | gamma-aminobutyric acid (GABA) A receptor, pi | ||
| 25984 | KRT23 | −2.48 | 218963_s_at | keratin 23 (histone deacetylase inducible) | Structural protein | BI(49) |
| 114569 | MAL2 | −2.45 | 224650_at | mal, T-cell differentiation protein 2 | transcytosis | BI(34) |
| 3854 | KRT6B | −2.39 | 213680_at | keratin 6B | Structural protein | BI(49) |
| 5275 | SERPINB13 | −2.34 | 211361_s_at | serpin peptidase inhibitor, clade B (ovalbumin) | Inhibit proteinases | AG(23) |
| 220 | ALDH1A3 | −2.31 | 203180_at | aldehyde dehydrogenase 1 family, member A3 | detoxification | |
| 144568 | A2ML1 | −2.29 | 1564307_a_at | alpha-2-macroglobulin-like 1 | Inhibit proteases | BI(35) |
| 647456 | CD24 | −2.29 | 208650_s_at | CD24 molecule | Cell receptor | |
| 5918 | RARRES1 | −2.28 | 221872_at | retinoic acid receptor responder 1 | Retinoic acid related | |
| 8796 | SCEL | −2.28 | 232056_at | sciellin | Cell differentiation | BI(30) |
| 6947 | TCN1 | −2.27 | 205513_at | transcobalamin I (vitamin B12 binding protein) | ||
| 5055 | SERPINB2 | −2.25 | 204614_at | serpin peptidase inhibitor, clade B (ovalbumin), | PAI-2 (proteinase inhibitor) | TM(25) |
| 3934 | LCN2 | −2.18 | 212531_at | lipocalin 2 (oncogene 24p3) | Granulocyte maturation | BI(36) |
| 4118 | MAL | −2.17 | 204777_s_at | mal, T-cell differentiation protein | T-cell differentiation | BI(33) |
| 8710 | SERPINB7 | −2.16 | 206421_s_at | serpin peptidase inhibitor, clade B Megsin | Proteinase inhibitor | AG(38) |
| 3713 | IVL | −2.11 | 214599_at | involucrin | Epidermal differentiation | |
| 26298 | EHF | −2.11 | 225645_at | Ets homologous factor | Transcriptional repressor | BI(37) |
| 9052 | GPRC5A | −2.1 | 203108_at | G protein-coupled receptor, family C, group 5, | Cell growth promotion | |
| 6698 | SPRR1A | −2.01 | 214549_x_at | small proline-rich protein 1A | CG | |
| 3860 | KRT13 | −2 | 207935_s_at | keratin 13 | Structural protein | BI(49) |
| 6699 | SPRR1B | −2 | 205064_at | small proline-rich protein 1B (cornifin) | Disrupts mitosis | CG |
| 6707 | SPRR3 | −2 | 232082_x_at | small proline-rich protein 3 | Neoplastic marker | BI |
| 1824 | DSC2 | −1.97 | 204751_x_at | desmocollin 2 |
CG- Cell and organ growth; AG- Angiogenesis, TM- Tissue and Matrix remodeling, GS- Growth-related signals; BI – Barrier and immune function, HY-Hypoxia related responses