TABLE 3.
Summary of reported cases of invasive Chaetomium infections
| Patient or reference | Age (y)/sex | Underlying medical conditiona | Site of infection | Speciesb | Treatment | Outcome |
|---|---|---|---|---|---|---|
| Patient 1 | 47/F | Leukemia/umbilical cord blood transplant | Multiple organs | C. perlucidum | L-AMB | Death |
| Patient 2 | 78/F | Asthma/chronic bronchiectasis | Lung | C. perlucidum | RML lobectomy | Cure |
| 11 | 19/F | Lymphoma/autologous BMT | Lung pleura | C. globosum* | Tienamycin, vancomycin, amikacin, AMB | Death |
| 21 | 19/M | AML | Lung | Chaetomium sp.** | Liposomal AMB | Death |
| 9, 17 | 31/M | Multiple myeloma/allogeneic BMT | Brain, lung | C. atrobrunneum | AMB, ITC | Death |
| 1 | 28/M | IVDU | Brain | C. strumarium | Oxacillin, cefotaxime, metronidazole | Death |
| 1 | 25/M | IVDU | Brain | C. strumarium | Amoxicillin, chloramphenicol, acyclovir, AMB, rifampin, isoniazid | Death |
| 1 | 20/M | IVDU | Brain | C. strumarium | Ceftriaxone, penicillin, acyclovir | Death |
| 10 | 24/M | ALL | Lung | C. globosum† | AMB | Death |
| 2 | 32/M | Renal transplant | Brain | C. atrobrunneum‡ | Unknown | Death |
| 4 | 73/F | None | Left maxillary sinus | Chaetomium sp. | Infundibulectomy | Cure |
a
Abbreviations: BMT, bone marrow transplant; RML, right middle lobe; IVDU, intravenous drug user; AML, acute myelogenous leukemia; ALL, acute lymphocytic leukemia.
b
*, there was no tissue invasion, and the authors were unable to determine the role of the organism in the death of the patient; **, the identification of this strain as C. globosum in the original reference has been questioned (7); †, this species is considered to be synonymous with C. cochliodes (18) (the isolate failed to produce fertile acomata for species identification); ‡, this strain was previously identified as C. globosum (1).