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. Author manuscript; available in PMC: 2009 Jan 13.
Published in final edited form as: Cell Cycle. 2008 Jul 1;7(13):1973–1982. doi: 10.4161/cc.7.13.6072

Figure 3.

Figure 3

(A) qPCR analysis of p53 gene targets 24h post Nutlin-3a treatment. Data are average of 2 independent experiments. (B) Western analysis showing (left panel) downregulation of Mcl-1 in parental SJSA, but not in SJSA-Hdmx cells following Nutlin-3a treatment and (C) rescue of Nutlin-3a induced Mcl-1 degradation by preincubation with zVAD to block caspase activation. SJSA (C) and BL cells (D) were treated with Nutlin-3a in the presence or absence of zVAD for 24h prior to blotting for the indicated proteins.