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. Author manuscript; available in PMC: 2009 Jan 13.
Published in final edited form as: J Med Chem. 2007 Apr 10;50(9):2078–2088. doi: 10.1021/jm061398y

Figure 2.

Figure 2

A: Comprehensive compartmental model of [11C]HED kinetics in the heart. Arrow thicknesses indicate relative magnitudes of rate constants. K1 has units of mL/min/g; all other rate constants have units of min-1. Cp = concentration in plasma; CE = concentration in extracellular space; Caxo = concentration in neuronal axoplasm; Cves = concentration in vesicles; NET = norepinephrine transporter; VMAT = vesicular monoamine transporter. B: Comprehensive compartmental model of a tracer with ‘ideal’ kinetic properties for kinetic modeling. C: Simplified compartmental model that could be used to analyze the myocardial kinetics of a PET tracer possessing the ‘ideal’ kinetic properties shown in B.